Description
Human p53 signaling PCR array detects gene expression of 68 genes.
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Description:
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein functions as a transcriptional activator of p53-regulated genes. The three major results of activation of p53 pathway are: cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. Gene List: APAF1; ATM; ATR; BAI1; BAX; BBC3; BID; CASP3; CASP8; CASP9; CCNB1; CCNB2;CCNB3; CCND1; CCND2;CCND3; CCNE1; CCNE2; CCNG1; CCNG2; CD82; CDK1; CDK2; CDK4; CDK6; CDKN1A; CDKN2A; CHEK1; CHEK2; CYCS; DDB2; EI24; FAS; GADD45A; GADD45B; GADD45G; GTSE1; IGF1; IGFBP3; LRDD; MDM2; MDM4; PERP; PMAIP1; PPM1D; PTEN; RCHY1; RFWD2; RPRM; RRM2; RRM2B; SERPINB5; SERPINE1; SESN1; SESN2; SESN3; SFN; SHISA5; SIAH1; STEAP3; THBS1; TNFRSF10B; TP53; TP53AIP1; TP53I3; TP73; TSC2; ZMAT3. Reaction Conditions: 95°C, 10 minutes. -> (95°C, 5 seconds. -> 60°C, 30 seconds.) for 50 cycles. Recommended Storage Conditions: -20°C Notes: To achieve accurate quantification, it is highly recommended to do replicates and reduce pipetting error. |
