Recombinant Human Ang-4 Protein

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Human Angiopoietin-4 (Ang-4) is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structural motifs of angiopoietins including the coiled-coiled domain near the amino-terminus and a fibrinogen-like domain at the C-terminus.

SKU: SKU49569 Categories: ,
SKU OPTIONS PriceQuantity
ANG4-100 50 ug (1 mg/ml) Please inquire
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ANG4-200 1 mg (1 mg/ml) Please inquire
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ANG4-300 100 mg (10 mg/ml) Please inquire
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ANG4-400 1 g (10 mg/ml) Please inquire
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ANG4-OEM Any size Please inquire
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Description

Description
Human Angiopoietin-4 (Ang-4) is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structural motifs of angiopoietins including the coiled-coiled domain near the amino-terminus and a fibrinogen-like domain at the C-terminus.  Human Ang-4 is an agonist that can bind and activate Tie-2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells.

Full Name
Angiopoietin-4

Source
E. coli

Species
Human

Accession #
Q9Y264

Molecule Weight
The mature recombinant human Ang-4 is a 57 kDa protein containing 480aa (N24-I503).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its ability to compete with biotinylated rhAng-2 for binding to immobilized Tie-2/Fc Chimera in a functional ELISA. Compared to rmAngiopoietin-3, rhAngiopoietin-4 is less effective in this competitive assay.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

Additional information

OPTIONS

50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size

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