Recombinant Human Neurotrophin-4
Recombinant Human Neurotrophin-4

Human Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3.
 
Name Cat# Description Price Qty
Human Neurotrophin-4
HNT4-100
50 μg,1 mg/ml
please inquire
Human Neurotrophin-4
HNT4 -200
1 mg,1 mg/ml
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Human Neurotrophin-4
HNT4 -400
100 mg,10 mg/ml
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Human Neurotrophin-4
HNT4 -400
1 g,10 mg/ml
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Human Neurotrophin-4
HNT4 -OEM,Any size
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Description
Human Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52% aa sequence identity with human β-NGF, BDNF, and NT-3.Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons.
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 Full Name
Human Neurotrophin-4

Source
E. coli

Species
Human

Accession #
P34130

Molecule Weight
The mature recombinant human Neurotrophin-4 consists of 130 amino acids (81-210) and has a predicted molecular mass of 14 kDa. NT-3 exists as a homodimer in solution.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. The ED50 for this effect is 0.3‑3 ng/mL.

 Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

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