Recombinant Human PDGF-CC Protein

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Platelet-Derived Growth Factors (PDGFs), also known as Glioma-derived growth factor (GDGF), and Osteosarcoma-derived Growth Factor (ODGF), are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains.

SKU: SKU49661 Categories: ,
SKU OPTIONS PriceQuantity
PDGFcc-100 50 ug (1 mg/ml) Please inquire
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PDGFcc-200 1 mg (1 mg/ml) Please inquire
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PDGFcc-300 100 mg (10 mg/ml) Please inquire
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PDGFcc-400 1 g (10 mg/ml) Please inquire
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PDGFcc-OEM Any size Please inquire
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Description

Description
Platelet-Derived Growth Factors (PDGFs), also known as Glioma-derived growth factor (GDGF), and Osteosarcoma-derived Growth Factor (ODGF), are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor.

Full Name
Platelet-Derived Growth Factor-CC

Source
E. coli

Species
Human

Accession #
NP_057289

Molecule Weight
The mature recombinant human PDGF-CC monomer is a 13.4 kDa protein containing 111aa (Val235-Gly345).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. The ED50 for this effect is 70-350 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

Additional information

OPTIONS

50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size

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