Recombinant Human Wnt-11 Protein
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The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation.
SKU | OPTIONS | Price | Quantity | ||
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WNT11-100 | 50 ug (1 mg/ml) | Please inquire | |||
WNT11-200 | 1 mg (1 mg/ml) | Please inquire | |||
WNT11-300 | 100 mg (10 mg/ml) | Please inquire | |||
WNT11-400 | 1 g (10 mg/ml) | Please inquire | |||
WNT11-OEM | Any size | Please inquire |
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Description
Description
The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Wnt family members are highly hydrophobic, and possess 22 to 24 conserved cysteines.
Wnt‑11 is required for cardiogenesis, organization of early muscle fibers, and branching morphogenesis of ureters, expressed in early development during gastrulation and in the perichondrium, lung mesenchyme and ureteric buds, but not in neuroepithelium. Wnt‑11 often, but not exclusively, signals by a non‑canonical pathway and may repress canonical signaling by other Wnts.
Full Name
Wingless-type MMTV Integration Site Family Member 11
Source
E. coli
Species
Human
Accession #
NP_004617
Molecule Weight
The mature recombinant human Wnt-11 is a 36.6 kDa protein containing 330aa (I25-K354).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured in a cell proliferation/survival assay using IEC‑18 rat small intestinal epithelial cells. The ED50 for this effect is 0.6-2.4 μg/mL.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
Additional information
OPTIONS | 50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size |
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