Recombinant Human BMP-8a Protein
Recombinant Human BMP-8a Protein

BMP-8, also known as osteogenic protein 2 (OP2), is a member of the Bone Morphogenetic Protein (BMPs) family, which is important for the development of bone and cartilage.
 
Name Cat# Description Price Qty
Human BMP-8a Protein
BMP8a-100
50 ug (1 mg/ml)
please inquire
Human BMP-8a Protein
BMP8a -200
1 mg (1 mg/ml)
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Human BMP-8a Protein
BMP8a -300
100 mg (10 mg/ml)
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Human BMP-8a Protein
BMP8a -400
1 g (10 mg/ml)
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Human BMP-8a Protein
BMP8a -OEM
Any size
please inquire

Description
BMP-8, also known as osteogenic protein 2 (OP2), is a member of the Bone Morphogenetic Protein (BMPs) family, which is important for the development of bone and cartilage. BMPs belong to the TGF-β superfamily of structurally related signaling proteins. BMP proteins are synthesized as large precursor molecules that are cleaved by proteolytic enzymes. The active form of BMPs can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. BMPs signal through type I and type II receptor tyrosine kinases and signal through SMAD proteins.
BMP‑8a is synthesized as a large precursor protein that is cleaved at a dibasic cleavage site (RTPR) between aa residues 263 and 264 to release a 139 aa carboxy‑terminal domain. Expression patterns of the BMP-8 genes indicate that they regulate aspects of cell proliferation and/or differentiation during spermatogenesis and formation of the placenta. BMP-8 is also highly expressed in osteosarcomas.

Full Name
Bone morphogenetic protein 8a

Source
E. coli

Species
Human

Accession #
AAP74599

Molecule Weight
The mature recombinant human BMP-8a consists of 139 amino acids (264-402) and has a predicted molecular mass of 16 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human BMP‑8a is present at 1 μg/mL, the concentration of recombinant human BMPR‑1A Fc Chimera that produces 50% of the optimal binding response is approximately 1.5‑6 μg/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

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