Description
FGF-12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
FGF12 is involved in nervous system development and function. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange.

Full Name
Fibroblast Growth Factor 12

Source
E. coli

Species
Human

Accession #
P61328

Molecule Weight
The mature recombinant human FGF-12 consists of 181 amino acids (1-181) and has a predicted molecular mass of 22.4 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its binding ability in a functional ELISA. Immobilized rhFGF R4/Fc Chimera at 5 µg/mL (100 µL/well) can bind rhFGF-12 with a linear range of 1.6-100 ng/mL.

 Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS