Description
Growth and Differentiation Factors (GDF) are members of the BMP family of TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis.
GDF-15, also called Macrophage inhibitory cytokine-1 (MIC-1), is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. It is also widely expressed in brain. GDF-15 has been shown to have various functions, including inhibition of production of tumor necrosis factor alpha (TNF-alpha ) from lipopolysaccharide-stimulated macrophages, induction of cartilage formation, early‑stage endochonadal bone formation, and promotion of neuronal survival.

Full Name
Growth and Differentiation Factor 15

Source
E. coli

Species
Human

Accession #
Q99988

Molecule Weight
The mature recombinant human GDF-15 is a 13 kDa protein (197-308aa).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS