Description
Insulin-like growth factor II belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. IGF-II is expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. IGF-II is a potent mitogenic growth factor. However, the growth-promoting function of IGF-II is limited to embryonic development.

Full Name
Insulin-like Growth Factor II

Source
E. coli

Species
Human

Accession #
P01344.1

Molecule Weight
The mature recombinant human IGF-II is a 7.5 kDa protein containing 70aa (A25-E91).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 1.5‑6 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS