Description
IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts.  It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system.  IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells.  It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.  

Full Name
Human Interleukin 11

Source
E. coli

Species
Human

Accession #
P20809.1

Molecule Weight
The mature recombinant human IL-11 consists of 179 amino acids (19-178) and has a predicted molecular mass of 19.3 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The ED50 for this effect is 0.02-0.12 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS