Recombinant Human Neurotrophin-3 (NT-3)
$0.00 – $2,696.54
Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family.
| SKU | OPTIONS | Price | Quantity | ||
|---|---|---|---|---|---|
| HNT3-100 | 100 ug,1 mg/ml | $317.24 | |||
| HNT3 -200 | 1 mg,1 mg/ml | $2,696.54 | |||
| HNT3 -OEM | Any size | Please inquire |
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Description
Description
Neurotrophins are growth factors that modulate growth, differentiation, and survival of neurons. Structure related proteins include neuron growth factor (NGF), brain derived neurogenic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5. They are highly homologous and share a similar structure of a tertiary folded, cysteine rich “knot”. Neurotrophins are critical to the development of the central and peripheral nervous system and they play important roles in injury induced neuron regeneration.
NT-3 is encoded by the NTF3 gene, and is the only neurotrophin that affects the development of the enteric nervous system. NT-3 primarily activates the TrkC tyrosine kinase receptor. In addition, NT-3 can activate Trk and TrkB kinase receptors in certain cell systems. NT-3 can also bind with low affinity to the low affinity NGF receptor. Dysregulation of NT-3 is known to be related with neuroblastoma, Alzhiemer’s, Huntington’s, and Parkinson’s Disease. Due to the broad cell poplulations affected by NT-3, the control of NT-3-TrkC pathway has become a target for therapeutical approach for neurogenic diseases.
Full Name
Human Neurotrophins-3
Source
E. coli
Species
Human
Accession #
NM_002527.4
Molecule Weight
NT-3 recombinant protein is a noncovalent linked homodimer. The 120 amino acid recombinant protein has a predicted molecular mass of approximately 13.6 kD as monomer, 26.5 kD as dimer
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml, corresponding to a specific activity of 2-5 x 104 units/mg.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
Additional information
| OPTIONS | 100 ug,1 mg/ml, 1 mg,1 mg/ml, Any size |
|---|
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