Description
Placenta growth factor (PlGF) is a member of the PDGF/VEGF family of growth factors. PlGF induces monocyte activation, migration, and production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.
Alternative splicing results in at least three human mature PlGF forms containing 131 (PlGF-1), 152 (PlGF-2), and 203 (PlGF-3) amino acids (aa) respectively. 

Full Name
Placenta growth factor 3

Source
E. coli

Species
Human

Accession #
P49763

Molecule Weight
The mature recombinant human PlGF-3 is a 22.8 kDa protein (19-221aa).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human VEGF R1/Flt‑1 Fc Chimera, aa 27-328 is immobilized at 2 μg/mL, 100 μL/well, the concentration of Recombinant Human PlGF-3 that produces 50% of the optimal binding response is approximately 0.6‑3 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS