Recombinant Human TGF-beta 2 Protein
Recombinant Human TGF-beta 2 Protein

TGF-beta 2 (transforming growth factor beta 1) is one of three closely related mammalian members, TGF-beta 1, -2 and -3 , of the large TGF-beta superfamily that share a characteristic cystine knot structure. These three TGF-beta isoforms are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition.
 
Name Cat# Description Price Qty
Human TGF-beta 2 Protein
TGFb 2-100
50 ug (1 mg/ml)
please inquire
Human TGF-beta 2 Protein
TGFb 2-200
1 mg (1 mg/ml)
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Human TGF-beta 2 Protein
TGFb 2-300
100 mg (10 mg/ml)
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Human TGF-beta 2 Protein
TGFb 2-400
1 g (10 mg/ml)
please inquire
Human TGF-beta 2 Protein
TGFb 2-OEM
Any size
please inquire

Description
TGF-beta 2 (transforming growth factor beta 1) is one of three closely related mammalian members, TGF-beta 1, -2 and -3 , of the large TGF-beta superfamily that share a characteristic cystine knot structure. These three TGF-beta isoforms are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. 
TGF-beta 2 signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II ser/thr kinase receptor termed TGF-beta  RII. This receptor then phosphorylates and activates another ser/thr kinase receptor, TGF-beta RI, or alternatively, ALK-1. The whole complex phosphorylates and activates Smad proteins that regulate transcription.

Full Name
Transforming growth factor beta 2

Source
E. coli

Species
Human

Accession #
P61812

Molecule Weight
The mature recombinant human TGF-beta 2 consists of 112 amino acids (303-414) and has a predicted molecular mass of 12.7 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. The ED50 for this effect is 0.025-0.25 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

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