Description
Vascular endothelial growth factor C (VEGF-C), also known as vascular permeability factor (VPF), is a potent polypeptide regulator of blood vessel function. VEGF promotes an array of responses in the endothelium, including hyperpermeability, endothelial cell growth, angiogenesis, and enhanced glucose transport. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure.

Full Name
Vascular endothelial growth factor C

Source
E. coli

Species
Human

Accession #
Q6FH59

Molecule Weight
The mature recombinant human VEGF-B is a 15.4 kDa protein (103-227aa).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. The ED50 for this effect is 1-5 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human VEGF R3/Flt‑4 Fc Chimera at 5 µg/mL (100 µL/well) can bind Recombinant Human VEGF‑C with an apparent Kd <40 nM.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS