Recombinant Human Wnt-7a Protein
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The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation.
SKU | OPTIONS | Price | Quantity | ||
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WNT7a-100 | 50 ug (1 mg/ml) | Please inquire | |||
WNT7a-200 | 1 mg (1 mg/ml) | Please inquire | |||
WNT7a-300 | 100 mg (10 mg/ml) | Please inquire | |||
WNT7a-400 | 1 g (10 mg/ml) | Please inquire | |||
WNT7a-OEM | Any size | Please inquire |
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Description
Description
The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Wnt family members are highly hydrophobic, and possess 22 to 24 conserved cysteines.
Human Wnt‑7a is expressed by epithelial and epithelially-derived cells of the placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Wnt-7a is frequently downregulated in leukemia and lung cancers, potentially affecting homeobox (HOX) gene expression, differentiation state and growth control. Roles for Wnt-7a have also been shown during formation of neural synapses, response of the uterus to estrogen and inflammatory cartilage destruction.
Full Name
Wingless-type MMTV Integration Site Family Member 7a
Source
E. coli
Species
Human
Accession #
O00755
Molecule Weight
The mature recombinant human Wnt-7a is a 35.5 kDa protein containing 318aa (L32-K349).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is 1-3 µg/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
Additional information
OPTIONS | 50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size |
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