New Products

Human BNDF

Human Brain-Derived Neurotrophic Factor (BDNF) is a member of the Nerve growth factor family. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Human NT-3 & NT-4

Neurotrophins are growth factors that modulate growth, differentiation, and survival of neurons. Structure related proteins include neuron growth factor (NGF), brain derived neurogenic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4). They are highly homologous and share a similar structure of a tertiary folded, cysteine rich "knot". Neurotrophins are critical to the development of the central and peripheral nervous system and they play important roles in injury induced neuron regeneration. NT-3 is encoded by the NTF3 gene, and is the only neurotrophin that affects the development of the enteric nervous system. NT-3 primarily activates the TrkC tyrosine kinase receptor. In addition, NT-3 can activate Trk and TrkB kinase receptors in certain cell systems. NT-3 can also bind with low affinity to the low affinity NGF receptor. Dysregulation of NT-3 is known to be related with neuroblastoma, Alzhiemer's, Huntington's, and Parkinson's Disease. Due to the broad cell poplulations affected by NT-3, the control of NT-3-TrkC pathway has become a target for therapeutical approach for neurogenic diseases. NT-4 promotes the development and survival of selected peripheral and CNS neurons. BDNF, which also activates TrkB, overlaps with many but not all NT-4 functions, a distinction that is likely due to differences in expression patterns. NT-4 induced TrkB signaling augments NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. It also promotes the proliferation of keratinocytes and accelerates hair follicle regression during the follicular cycle. NT-4 is secreted by activated T cells and granulocytes at sites of inflammation where it contributes to tissue regeneration.

ApoA1 (Apolipoprotein A1) is synthesized in the liver and small intestine, and is the major protein component of high density lipoprotein (HDL) in the plasma. ApoA1 has a unique ability to capture and solubilize free cholesterol, and promotes cholesterol efflux from tissues to the liver for excretion. The process, called reverse cholesterol transport, is thought to inhibit atherogenesis. The recombinant human ApoA1 consists of 244 amino acids and predicts a molecular mass of 28.2 KD.
Recombinant Bovine Enterokinase (rbEK) Protein

Enterokinase (EK) is an enzyme produced by cells of the duodenum and involved in human digestion. It plays a role of turning trypsinogen to its active form trypsin, and indirectly activates the pancreatic digestive enzymes. Enterokinase is a specific protease that cleaves after a lysine preceded by four aspartic acids: Asp-Asp-Asp-Asp-Lys. Enterokinase will not work if the recognition site is followed by a proline.
Recombinant BTX (Light Chain) Protein

Botulinum neurotoxin type A is one of the seven serotypes of Botulinum Neurotoxins (BoNTs) produced by various strains of Clostridium botulinum. BoNTs are synthesized as inactive single chain protein precursors and activated by proteolytic cleavage to generate disulfide-linked two-chain proteins. The 50 kDa light chain contains the catalytic domain, whereas the 100 kDa heavy chain contains an internal translocation domain and a receptor binding domain. BoNTs are the most potent protein toxins for humans. As zinc proteases, they cleave SNARE proteins to elicit flaccid paralysis in botulism by blocking acetylcholine release at the neuromuscular junction. E. coli-expressed recombinant light chains are active proteases. However, they are not toxic because they cannot enter into host cells in the absence of the heavy chains.

Immobilized metal ion affinity chromatography (IMAC) technique has been widely used to purify native proteins with an intrinsic affinity to metal ions. The major application is for the purification of His-tagged recombinant proteins that can bind nickel, cobalt, and copper ions. IMAC is also used for isolating phosphorylated proteins and zinc finger or copper-binding proteins. MCLAB’s IMAC products are available in resins and cartridges forms containing nitrilotriacetic acid (NTA) or iminodiacetic acid (IDA) as the chelating ligand loaded with a broad range of transition metals, including copper (Cu), nickel (Ni), zinc (Zn), cobalt (Co), iron (Fe), and gallium (Ga), aluminium (Al).
Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Human Nicotinamide Phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10.
MutS Protein (Thermus aquaticus)

The MutS DNA mismatch protein recognizes heteroduplex DNAs containing mispaired or unpaired bases. This Muts protein binds in vitro to heteroduplex DNAs containing mispaired or unpaired bases over a wide temperature range from 4 to 70 °C and has a thermostable ATPase activity. This thermostable Taq MutS is active at temperature between 0 to 75°C. Since Taq MutS efficiently binds to 1-4 bases deletion (or insertion) and mismatch base pairs of GT, CT and AG, it is useful for detecting these mutations. Mutations can be detected in polyacrylamide gels or on a solid phase such as Ni agarose or beads or magnetic Ni-NTA particles.
Human Alkyl Adenine DNA Glycosylase

Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 306 amino acids (1-298 a.a.) and having a molecular mass of 33.9kDa (Molecular weight on SDS-PAGE will appear higher).
Endonuclease VIII

Endonuclease VIII from E. coli acts as both an N-glycosylase and an AP-lyase. The N-glycosylase activity releases damaged pyrimidines from double-stranded DNA, generating an apurinic (AP site). The AP-lyase activity cleaves 3´ and 5´ to the AP site leaving a 5´ phosphate and a 3´ phosphate. Damaged bases recognized and removed by Endonuclease VIII include urea, 5, 6- dihydroxythymine, thymine glycol, 5-hydroxy-5- methylhydantoin, uracil glycol, 6-hydroxy-5, 6-dihydrothymine and methyltartronylurea. While Endonuclease VIII is similar to Endonuclease III, Endonuclease VIII has β and δ lyase activity while Endonuclease III has only β lyase activity.
Endonuclease V

Endonuclease V, (Endo V) is a 3'-endonuclease involved in DNA repair, which initiates removal of deaminated bases from damaged DNA, including uracil, hypoxanthine, and xanthine. Endonuclease V is also active toward abasic sites and urea sites, base pair mismatches, flap and pseudo Y structures, and small insertions/deletions in DNA molecules. The cleavage site generated by Endonuclease V is at the second phosphodiester bond 3' to a lesion.
Endonuclease III (Nth)

Endonuclease III (Nth) protein from E. coli acts as both N-glycosylase and a AP-lyase. The N-glycosylase activity releases damaged pyrimidines from double-stranded DNA, generating a basic (AP site). The AP-lyase activity of the enzyme cleaves 3´ to the AP site leaving a 5´ phosphate and a 3´ ring opened sugar. Some of the damaged bases recognized and removed by Endouclease III include urea, 5, 6 dihydroxythymine, thymine glycol, 5-hydroxy-5 methylhydanton, uracil glycol, 6-hydroxy-5, 6-dihdrothimine and methyltartronylurea.
MCMax Cell-Free DNA Extraction Kit

MCMax Cell-Free DNA Extraction Kit MCMax Cell-Free DNA Extraction Kit is designed to purify cell-free DNA (cfDNA) from 0.2-10 ml plasma samples. The kit contains everything necessary for purification, with no preprocessing required. The purified cell-free DNA is of high quality with little genomic DNA contamination and is ready for use in downstream applications such as qPCR, next-generation sequencing and digital PCR.
MC Cloning 5’/3’-RACE Kit

The MC Cloning 5'/3' RACE Kit The MC Cloning 5'/3' RACE Kit provides a convenient method for performing both 5' and 3' rapid amplifications of cDNA ends (RACE) with optimized primers for cloning any gene of interest. The SmartRT reverse transcriptase allows to synthesize complete cDNA by SMART (Switching Mechanism At 5' end of RNA Transcript) cDNA synthesis technology. With a few additional nucleotides added to the 3' end of the first-strand cDNA, 5' SMART universal oligo, containing terminal complementation to the nucleotides at 3' end of the first-strand cDNA, can be annealed to first-strand cDNA tail and serves as an extended template for RT. The switch of template from mRNA to 5' SMART universal oligo produces a complete cDNA copy of transcript RNA with 5' SMART universal oligo at the end. The cDNA transcript from SmartRT can be used directly in 5' and 3' RACE with MCLAB's I-5™ 2X High-Fidelity Master Mix.
BirA Biotin-protein Ligase

Biotin-protein ligase activates biotin to form biotinyl 5' adenylate and transfers the biotin to biotin-accepting proteins. It also functions as a biotin operon repressor. The protein is encoded by the birA gene.
Recombinant Human NGF R100W Mutant

Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF acts via at least two receptors on the surface of cells, TrkA and p75 receptors to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In addition to its neurotropic activities, studies indicated that NGF may also have an important role in the regulation of the immune system. NGF holds great therapeutic promise for Alzheimer's disease, diabetic neuropathies, ophthalmic diseases, and dermatological ulcers. However, the necessity for systemic delivery has hampered the clinical applications of NGF due to its potent pro-nociceptive action. A "painless" human NGF (hNGF R100W) mutant has been engineered. It has equal neurotrophic potency to hNGF but a lower nociceptive activity.
RNase R

RNase R is an E. coli exoribonuclease which exhibits 3' to 5' exonuclease activity, efficiently digesting nearly all linear RNA species. This enzyme does not digest circular, lariat, or double stranded RNA with short 3 overhangs (less than seven nucleotides). RNase R is ideally suited to the study of lariat RNA produced by traditional splicing, as well as circRNAs which arise through back-splicing. By removing linear RNAs from cellular or RNA extracts, RNase R greatly facilitates the identification of circular species through RNA-sequencing.
RNase H, Tth

RNase H is an endoribonuclease which degrades the RNA strand of RNA/DNA hybrid molecules. RNase H digestion produces ribonucleotide molecules with 5'-phosphate and 3'-hydroxyl termini. RNAse H is nearly inactive against single or double-stranded RNA molecules. RNase H from the thermophilic eubacterium Thermus thermophilus HB8 is thermostable, has optimal activity above 65°C and is active up to 95°C, making it useful for a broad range of applications.
RNase H, Bst

RNase H is an endoribonuclease which degrades the RNA strand of RNA/DNA hybrid molecules. RNase H digestion produces ribonucleotide molecules with 5'-phosphate and 3'-hydroxyl termini. RNAse H is nearly inactive against single or double-stranded RNA molecules. RNase H from the thermophilic bacterium Bacillus stearothermophilus is thermostable, has optimal activity above 65°C and making it useful for a broad range of applications.
Oligo d(T)18-24 Magnetic Beads, Oligo d(T) bound Plate

Oligo d(T)18-24 Magnetic Beads are polymer based affinity matrix for small-scale, rapid isolation of mRNA from crude cell lysates or tissues. The isolation occurs through the hybridization of covalently coupled oligo d(T)18-24 to the poly(A) region present in most eukaryotic mRNA. The isolated mRNA can be used directly in most downstream applications in molecular biology, e.g. RT-PCR, cDNA library construction, in vitro translation experiments, and gene expression analysis. Oligo d(T) Bound Plate is specifically designed for a rapid, low-cost isolation of mRNA in a high throughput format using a proprietary linker technology. The oligo d(T)18-24 are covalently linked to the surface of each well of the plate for small-scale, rapid isolation of mRNA from crude cell lysates and tissues. The isolated mRNA can be used directly in most downstream applications in molecular biology, e.g. RT-PCR, cDNA library construction, in vitro translation experiments, and gene expression analysis.
Direct RNA Solution

Direct RNA Solution is a RT-PCR ready RNA extraction solution. It can extract RNA from a variety of sample types, such as whole blood, tissues, body fluids, cultured cells, plant leaves, roots, flowers, fungi, and bacteria. It employs a unique method to release RNA from cells without lysing the cells. After a short incubation of the sample with the Direct RNA Solution, the RNA is released in the supernatant, which can be used directly in a standard RT-PCR, or frozen for long-term storage.
Recombinant Human Growth Hormone (rhGH)

Growth Hormone (GH) plays an important role in growth control. The major role of GH in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts, and also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Recombinant Human Growth Hormone (rhGH) produced in E. coli is a single non-glycosylated polypeptide chain containing 191 amino acids. A fully biologically active molecule, rhGH has a molecular mass of 22.1 kDa analyzed by reducing SDS-PAGE.
Betaine Solution (5M)

Betaine is a PCR enhancing agent that has been used successfully for increasing yield and specificity of PCR products. It equalizes the contribution of GC- and AT-base pairing to the stability of the DNA duplex. Therefore, it's very useful to GC-rich PCR fragment amplification. MCLAB’s betaine solution is 5M in MilliQ H2O with DNase and RNase free.
Human Trypsin-1

Recombinant Human Trypsin-1 is a genetically engineered protein expressed in E. coli and purified by standard chromatography techniques. Recombinant Human Trypsin-1 is free from any animal and human sources. There are no contaminating enzyme activities such as carboxypeptidase A and chymotrypsin. No protease inhibitors such as PMSF are contained in the preparation.
dGTP BrightDye® Terminator Cycle Sequencing Kit

The dGTP BrightDye® Terminator Cycle Sequencing Kit is optimized for sequencing GC-rich and other difficult-to-sequence templates. The dGTP BrightDye® Terminator Kit comprises dGTP, replacing dITP, which facilitates the extension through those difficult-to-sequence regions without early signal loss. This is compatible with commercially available BigDye terminator, V3.0.
BrightDye® Terminator Cycle Sequencing Kit

The BrightDye® Terminator Cycle Sequencing Kit is designed for de novo sequencing, resequencing, PCR product, plasmid, fosmid, and BAC templates by utilizing highly flexible chemistry.
NGS Library Distribution Kit

MCLab's NGS Library Distribution Kit offers fast and reliable separation, sizing and quantification of DNA or RNA libraries utilizing Capillary Electrophoresis technology, which can separate molecules with a single base difference.
Blunting Express Kit

The Blunting Express Kit can be used to generate blunt-ended DNA fragments for subsequent use in ligation, cloning, cDNA construction, and MCLAB's Topomize Amplicon Library Prep Kit (Cat# TopoA-50A or TopoA-50B).
2X MCAmp Library Amplification Master Mix

The 2X MCAmp library amplification master mix has been specially formulated to provide accurate and robust amplification of NGS (next-generation sequencing) library fragments.
5´ DNA Adenylation Kit

5´ DNA Adenylation Kit is for the enzymatic synthesis of 5 adenylated ssDNA linkers. The kit is optimized to produce the adenylated DNA with or without 3´ terminator. The 5´ DNA adenylation kit can simply and efficiently generate greater than 95% conversion of pDNA to AppDNA.


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